Local Synaptic Inputs Support Opposing, Network-Specific Odor Representations in a Widely Projecting Modulatory Neuron

Authors

Xiaonan Zhang, University of Maryland at College Park
Kaylynn Coates, West Virginia University
Andrew Dacks, West Virginia University
Cengiz Günay, Georgia Gwinnett College
J. Scott Lauritzen, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, United States
Feng Li, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, United States
Steven A. Calle-Schuler, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, United States
Davi Bock, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, United States
Quentin Gaudry, University of Maryland at College Park

Author ORCID Identifier

https://orcid.org/0000-0003-3181-3648

https://orcid.org/0000-0003-2592-8908

https://orcid.org/0000-0002-6805-4211

https://orcid.org/0000-0001-7586-571X

N/A

https://orcid.org/0000-0002-6658-9175

N/A

https://orcid.org/0000-0002-8218-7926

https://orcid.org/0000-0002-6869-1253

Document Type

Article

Publication Date

2019

Department/Program/Center

Biology

Abstract

Serotonin plays different roles across networks within the same sensory modality. Previously, we used whole-cell electrophysiology in Drosophila to show that serotonergic neurons innervating the first olfactory relay are inhibited by odorants (Zhang and Gaudry, 2016). Here we show that network-spanning serotonergic neurons segregate information about stimulus features, odor intensity and identity, by using opposing coding schemes in different olfactory neuropil. A pair of serotonergic neurons (the CSDns) innervate the antennal lobe and lateral horn, which are first and second order neuropils. CSDn processes in the antennal lobe are inhibited by odors in an identity independent manner. In the lateral horn, CSDn processes are excited in an odor identity dependent manner. Using functional imaging, modeling, and EM reconstruction, we demonstrate that antennal lobe derived inhibition arises from local GABAergic inputs and acts as a means of gain control on branch-specific inputs that the CSDns receive within the lateral horn.

Digital Commons Citation

Zhang, Xiaonan; Coates, Kaylynn; Dacks, Andrew; Günay, Cengiz; Lauritzen, J. Scott; Li, Feng; Calle-Schuler, Steven A.; Bock, Davi; and Gaudry, Quentin, "Local Synaptic Inputs Support Opposing, Network-Specific Odor Representations in a Widely Projecting Modulatory Neuron" (2019). Faculty & Staff Scholarship. 1963.
https://researchrepository.wvu.edu/faculty_publications/1963

Source Citation

Zhang, X., Coates, K., Dacks, A., Günay, C., Lauritzen, J. S., Li, F., Calle-Schuler, S. A., Bock, D., & Gaudry, Q. (2019). Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron. eLife, 8. https://doi.org/10.7554/elife.46839

Comments

© 2019, Zhang et al.

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