Document Type
Article
Publication Date
2016
College/Unit
School of Medicine
Department/Program/Center
Not Listed
Abstract
Background: Cigarette smoke exposure during prenatal and early postnatal periods increases the incidence of a variety of abnormal behaviors later in life. The purpose of this study was to identify the possible critical period of susceptibility to cigarette smoke exposure and evaluate the possibe effects of cigarette smoke during early life on brain-derived neurotrophic factor/neurotrophic tyrosine kinase receptor B signaling in the brain.
Methods: Three different age of imprinting control region mice were exposed to cigarette smoke or filtered air for 10 consecutive days beginning on either gestational day 7 by maternal exposure, or postnatal days 2 or 21 by direct inhalation. A series of behavioral profiles and neurotrophins in brain were measured 24 hours after mice received acute restraint stress for 1 hour on postnatal day 59.
Results: Cigarette smoke exposure in gestational day 7 and postnatal day 2 produced depression-like behaviors as evidenced by significantly increased immobility in both tail suspension and forced-swim test. Increased entry latencies, but not ambulation in the open field test, were also observed in the gestational day 7 and postnatal day 2 cigarette smoke exposure groups. Genetic analysis showed that gestational day 7 cigarette smoke exposure significantly altered mRNA level of brain derived neurotrophic factor/tyrosine kinase receptor B in the hippocampus. However, behavioral profiles and brain-derived neurotrophic factor/tyrosine kinase receptor B signaling were not significantly changed in PND21 cigarette smoke exposure group compared with FA group.
Conclusions: These results suggest that a critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life.
Digital Commons Citation
Xiao, Lan PhD; Kish, Vincent L. MS; Benders, Katherine M. MS; and Wu, Zhong-Xin PhD, "Prenatal and Early Postnatal Exposure to Cigarette Smoke Decreases BDNF/TrkB Signaling and Increases Abnormal Behaviors Later in Life" (2016). Faculty & Staff Scholarship. 2178.
https://researchrepository.wvu.edu/faculty_publications/2178
Source Citation
Xia, Z., Cholewa, J., Zhao, Y., Yang, Y.-Q., Shang, H.-Y., Guimarães-Ferreira, L., … Zanchi, N. (2016). Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice. Nutrients, 8(5), 246. https://doi.org/10.3390/nu8050246
Comments
© The Author 2015. Published by Oxford University Press on behalf of CINP. International Journal of Neuropsychopharmacology, (2016) 19(5): 1–11 doi:10.1093/ijnp/pyv117 Advance Access publication October 26, 2015 Research Article 1 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.