Document Type
Article
Publication Date
2019
Abstract
ABSTRACT: Aging is a complex and integrated gradual deterioration of cellular activities in specific organs of the body, which is associated with increased mortality. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, neurovascular disorders, and neurodegenerative diseases. There are nine tentative hallmarks of aging. In addition, several of these hallmarks are increasingly being associated with acute brain injury conditions. In this review, we consider the genes and their functional pathways involved in brain aging as a means of developing new strategies for therapies targeted to the neuropathological processes themselves, but also as targets for many age-related brain diseases. A single microRNA (miR), which is a short, non-coding RNA species, has the potential for targeting many genes simultaneously and, like practically all other cellular processes, genes associated with many features of brain aging and injury are regulated by miRs. We highlight how certain miRs can mediate deregulation of genes involved in neuroinflammation, acute neuronal injury and chronic neurodegenerative diseases. Finally, we review the recent progress in the development of effective strategies to block specific miR functions and discuss future approaches with the prediction that anti-miR drugs may soon be used in the clinic.
Digital Commons Citation
Sarkar, Saumyendra N.; Russell, Ashley E.; Engler-Chiurazzi, Russell Elizabeth B.; Porter, Keyana N.; and Simpkins, James W., "MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma" (2019). Faculty & Staff Scholarship. 2189.
https://researchrepository.wvu.edu/faculty_publications/2189
Source Citation
Sarkar, S. N., Russell, A. E., Engler-Chiurazzi, E. B., Porter, K. N., & Simpkins, J. W. (2019). MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma. Aging and Disease, 10(2), 329. https://doi.org/10.14336/ad.2018.0409
Comments
© 2018 Sarkar SN et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.