Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

Authors

Nam P. Nguyen, Howard University
Siyoung Jang, University of Arizona
Jacqueline Vock, Lindenhofspital
Vincent Vinh-Hung, University Hospitals of Geneva
Alexander Chi, West Virginia University
Paul Vos, East Carolina University
Judith Pugh, University of Arizona
Richard A. Vo, University of Virginia
Misty Ceizyk, University of Arizona
Anand Desai, Akron City Hospital
Lexie Smith-Raymond, University of Arizona
the International Geriatric Radiotherapy Group

Document Type

Article

Publication Date

2014

College/Unit

School of Medicine

Department/Program/Center

Radiation Oncology

Abstract

Background

In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.

Methods

A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).

Results

At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.

Conclusions

IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.

Digital Commons Citation

Nguyen, Nam P.; Jang, Siyoung; Vock, Jacqueline; Vinh-Hung, Vincent; Chi, Alexander; Vos, Paul; Pugh, Judith; Vo, Richard A.; Ceizyk, Misty; Desai, Anand; Smith-Raymond, Lexie; and the International Geriatric Radiotherapy Group, "Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer" (2014). Faculty & Staff Scholarship. 2544.
https://researchrepository.wvu.edu/faculty_publications/2544

Source Citation

Nguyen, N.P., Jang, S., Vock, J. et al. Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer. BMC Cancer 14, 265 (2014). https://doi.org/10.1186/1471-2407-14-265

Comments

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.