Feasibility of Tomotherapy-Based Image-Guided Radiotherapy for Locally Advanced Oropharyngeal Cancer

Authors

Nam P. Nguyen, University of Arizona
Misty Ceizyk, University of Arizona
Paul Vos, East Carolina University
Michael Betz, Hirslanden Radiation Oncology Institute
Alexander Chi, West Virginia University
Fabio Almeida, Southwest PET-CT Institute
Rick Davis, University of Arizona
Benjamin Slane, University of Arizona
Steven Gelumbauskas, University of Arizona
Lexie Smith-Raymond, University of Arizona
Dave Abraham, University of Arizona
Michelle Stevie, University of Arizona
Siyoung Jang, University of Arizona
Vincent Vinh-Hung, University Hospitals of Geneva

Author ORCID Identifier

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https://orcid.org/0000-0001-9996-5627

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https://orcid.org/0000-0002-9763-5867

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https://orcid.org/0000-0002-6403-6120

Document Type

Article

Publication Date

2013

College/Unit

School of Medicine

Department/Program/Center

Radiation Oncology

Abstract

Purpose

The study aims to assess the feasibility of tomotherapy-based image-guided (IGRT) radiotherapy for locally advanced oropharyngeal cancer. A retrospective review of 33 patients undergoing concurrent chemoradiation for locally advanced oropharyngeal cancers was conducted. Radiotherapy planning, treatment toxicity and loco-regional control were assessed.

Results

At a median follow-up of 32 months (6–47 months), no patient developed loco-regional recurrence. Two patients (6%) developed distant metastases. Grade 3–4 acute toxicity was respectively 72% and 25% for mucositis and gastrointestinal toxicity. Two patients (6%) had long-term dependence on tube feedings. Dose-volume histogram demonstrated excellent target volume coverage and low radiation dose to the organs at risk for complications.

Conclusions and clinical relevance

IGRT provides excellent loco-regional control but acute toxicity remains significant and needs to be addressed in future prospective trials. The feasibility of Tomotherapy to decrease radiation dose to the normal tissues merits further investigations.

Digital Commons Citation

Nguyen, Nam P.; Ceizyk, Misty; Vos, Paul; Betz, Michael; Chi, Alexander; Almeida, Fabio; Davis, Rick; Slane, Benjamin; Gelumbauskas, Steven; Smith-Raymond, Lexie; Abraham, Dave; Stevie, Michelle; Jang, Siyoung; and Vinh-Hung, Vincent, "Feasibility of Tomotherapy-Based Image-Guided Radiotherapy for Locally Advanced Oropharyngeal Cancer" (2013). Faculty & Staff Scholarship. 2644.
https://researchrepository.wvu.edu/faculty_publications/2644

Source Citation

Nguyen NP, Ceizyk M, Vos P, Betz M, Chi A, Almeida F, et al. (2013) Feasibility of Tomotherapy-Based Image-Guided Radiotherapy for Locally Advanced Oropharyngeal Cancer. PLoS ONE 8(3): e60268. https://doi.org/10.1371/journal.pone.0060268

Comments

© 2013 Nguyen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.