Effects of Smoking and Genotype on the PSR Index of Periodontal Disease in Adults Aged 18–49

Authors

Deborah E. Polk, University of Pittsburgh
Xiaojing Wang, University of Pittsburgh
Eleanor Feingold, University of Pittsburgh
John R. Shaffer, University of Pittsburgh
Daniel E. Weeks, University of Pittsburgh
Robert J. Weyant, University of Pittsburgh
Richard J. Crout, West Virginia University
Daniel W. McNeil, West Virginia University
Mary L. Marazita, University of Pittsburgh

Author ORCID Identifier

https://orcid.org/0000-0002-1402-4068

N/A

https://orcid.org/0000-0003-2898-6484

https://orcid.org/0000-0003-1897-1131

https://orcid.org/0000-0001-9410-7228

https://orcid.org/0000-0002-5252-9120

https://orcid.org/0000-0002-7695-5685

https://orcid.org/0000-0002-0766-8455

https://orcid.org/0000-0002-2648-2832

Document Type

Article

Publication Date

2013

College/Unit

School of Dentistry

Department/Program/Center

Periodontics

Abstract

Studies have found both genetic and environmental influences on chronic periodontitis. The purpose of this study was to examine the relationships among previously identified genetic variants, smoking status, and two periodontal disease-related phenotypes (PSR1 and PSR2) in 625 Caucasian adults (aged 18–49 years). The PSR Index was used to classify participants as affected or unaffected under the PSR1 and PSR2 phenotype definitions. Using logistic regression, we found that the form of the relationship varied by single nucleotide polymorphism (SNP): For rs10457525 and rs12630931, the effects of smoking and genotype on risk were additive; whereas for rs10457526 and rs733048, smoking was not independently associated with affected status once genotype was taken into consideration. In contrast, smoking moderated the relationships of rs3870371 and rs733048 with affected status such that former and never smokers with select genotypes were at increased genetic risk. Thus, for several groups, knowledge of genotype may refine the risk prediction over that which can be determined by knowledge of smoking status alone. Future studies should replicate these findings. These findings provide the foundation for the exploration of novel pathways by which periodontitis may occur.

Digital Commons Citation

Polk, Deborah E.; Wang, Xiaojing; Feingold, Eleanor; Shaffer, John R.; Weeks, Daniel E.; Weyant, Robert J.; Crout, Richard J.; McNeil, Daniel W.; and Marazita, Mary L., "Effects of Smoking and Genotype on the PSR Index of Periodontal Disease in Adults Aged 18–49" (2013). Faculty & Staff Scholarship. 2678.
https://researchrepository.wvu.edu/faculty_publications/2678

Source Citation

Polk, D. E., Wang, X., Feingold, E., Shaffer, J. R., Weeks, D. E., Weyant, R. J., Crout, R. J., McNeil, D. W., & Marazita, M. L. (2012). Effects of Smoking and Genotype on the PSR Index of Periodontal Disease in Adults Aged 18–49. International Journal of Environmental Research and Public Health, 9(8), 2839–2850. https://doi.org/10.3390/ijerph9082839