Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

Authors

• Selina Wray, University College London Institute of Neurology
• Matthew Self, Coriell Institute for Medical Research
• NINDS Parkinson's Disease iPSC Consortium
• NINDS Huntington's Disease iPSC Consortium
• NINDS ALS iPSC Consortium
• Patrick A. Lewis, University College London Institute of Neurology
• Jan-Willem Taanman, University College London Institute of Neurology
• Natalie S. Ryan, University College London Institute of Neurology
• Colin J. Mahoney, University College London Institute of Neurology
• Yuying Liang, University College London Institute of Neurology
• Michael J. Devine, University College London Institute of Neurology
• Una-Marie Sheerin, University College London Institute of Neurology
• Henry Houlden, University College London Institute of Neurology
• Huw R. Morris, University of Cardiff
• Daniel Healy, University College London Institute of Neurology
• Jose-Felix Marti-Masso, Hospital Donastia
• Elisavet Preza, University College London Institute of Neurology
• Suzanne Barker, University College London Institute of Neurology,
• Margret Sutherland, National Institute for Neurological Disorders and Stroke
• Roderick A. Corriveau, National Institute for Neurological Disorders and Stroke
• Michael D'Andrea, Coriell Institute for Medical Research
• Anthony H V Schapira, University College London Institute of Neurology
• Ryan J. Uitti, University College London Institute of Neurology
• Jaroslaw Slawek, Medical University of Gdansk
• Ludwig Gutmann, West Virginia University
• Bradley F. Boeve, Mayo Clinic
• Kevin Boylan, Mayo Clinic
• A Jon Stoessl, University of British Columbia
• Owne A. Ross, Mayo Clinic
• Nicholas J. Maragakis, Johns Hopkins University
• Serge E. Przedborski, Columbia University
• Steven Finkbeiner, University of California, San Francisco
• Jeffery D. Rothstein, Johns Hopkins University
• Zbigniew K. Wszolek, Mayo Clinic
• Martin N. Rossor, University College London Institute of Neurology
• John Hardy, University College London Institute of Neurology

Author ORCID Identifier

https://orcid.org/0000-0003-3062-7050

N/A

N/A

N/A

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https://orcid.org/0000-0003-4537-0489

https://orcid.org/0000-0002-5476-9785

https://orcid.org/0000-0003-0361-7455

https://orcid.org/0000-0002-5878-3859

N/A

https://orcid.org/0000-0001-6076-3382

https://orcid.org/0000-0002-7061-760X

https://orcid.org/0000-0002-2866-7777

https://orcid.org/0000-0002-5473-3774

N/A

https://orcid.org/0000-0001-8428-4386

https://orcid.org/0000-0003-4082-4621

https://orcid.org/0000-0003-0497-2854

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https://orcid.org/0000-0002-6954-9240

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N/A

https://orcid.org/0000-0001-6816-0877

https://orcid.org/0000-0003-1600-6178

https://orcid.org/0000-0002-4153-8187

N/A

https://orcid.org/0000-0002-9778-7246

https://orcid.org/0000-0003-4813-756X

https://orcid.org/0000-0002-7311-9614

https://orcid.org/0000-0002-7283-3883

https://orcid.org/0000-0002-3480-394X

N/A

N/A

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Document Type

Article

Publication Date

2013

College/Unit

Eberly College of Arts and Sciences

Department/Program/Center

Neurology

Abstract

Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.

Digital Commons Citation

Wray, Selina; Self, Matthew; NINDS Parkinson's Disease iPSC Consortium; NINDS Huntington's Disease iPSC Consortium; NINDS ALS iPSC Consortium; Lewis, Patrick A.; Taanman, Jan-Willem; Ryan, Natalie S.; Mahoney, Colin J.; Liang, Yuying; Devine, Michael J.; Sheerin, Una-Marie; Houlden, Henry; Morris, Huw R.; Healy, Daniel; Marti-Masso, Jose-Felix; Preza, Elisavet; Barker, Suzanne; Sutherland, Margret; Corriveau, Roderick A.; D'Andrea, Michael; Schapira, Anthony H V; Uitti, Ryan J.; Slawek, Jaroslaw; Gutmann, Ludwig; Boeve, Bradley F.; Boylan, Kevin; Stoessl, A Jon; Ross, Owne A.; Maragakis, Nicholas J.; Przedborski, Serge E.; Finkbeiner, Steven; Rothstein, Jeffery D.; Wszolek, Zbigniew K.; Rossor, Martin N.; and Hardy, John, "Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research" (2013). Faculty & Staff Scholarship. 2682.
https://researchrepository.wvu.edu/faculty_publications/2682

Source Citation

Wray S, Self M, NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Lewis PA, et al. (2012) Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research. PLoS ONE 7(8): e43099. https://doi.org/10.1371/journal.pone.0043099

Comments

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.