Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

Authors

Selina Wray, University College London Institute of Neurology
Matthew Self, Coriell Institute for Medical Research
NINDS Parkinson's Disease iPSC Consortium
NINDS Huntington's Disease iPSC Consortium
NINDS ALS iPSC Consortium
Patrick A. Lewis, University College London Institute of Neurology
Jan-Willem Taanman, University College London Institute of Neurology
Natalie S. Ryan, University College London Institute of Neurology
Colin J. Mahoney, University College London Institute of Neurology
Yuying Liang, University College London Institute of Neurology
Michael J. Devine, University College London Institute of Neurology
Una-Marie Sheerin, University College London Institute of Neurology
Henry Houlden, University College London Institute of Neurology
Huw R. Morris, University of Cardiff
Daniel Healy, University College London Institute of Neurology
Jose-Felix Marti-Masso, Hospital Donastia
Elisavet Preza, University College London Institute of Neurology
Suzanne Barker, University College London Institute of Neurology,
Margret Sutherland, National Institute for Neurological Disorders and Stroke
Roderick A. Corriveau, National Institute for Neurological Disorders and Stroke
Michael D'Andrea, Coriell Institute for Medical Research
Anthony H V Schapira, University College London Institute of Neurology
Ryan J. Uitti, University College London Institute of Neurology
Jaroslaw Slawek, Medical University of Gdansk
Ludwig Gutmann, West Virginia University
Bradley F. Boeve, Mayo Clinic
Kevin Boylan, Mayo Clinic
A Jon Stoessl, University of British Columbia
Owne A. Ross, Mayo Clinic
Nicholas J. Maragakis, Johns Hopkins University
Serge E. Przedborski, Columbia University
Steven Finkbeiner, University of California, San Francisco
Jeffery D. Rothstein, Johns Hopkins University
Zbigniew K. Wszolek, Mayo Clinic
Martin N. Rossor, University College London Institute of Neurology
John Hardy, University College London Institute of Neurology

Document Type

Article

Publication Date

2013

College/Unit

Eberly College of Arts and Sciences

Department/Program/Center

Neurology

Abstract

Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.

Digital Commons Citation

Wray, Selina; Self, Matthew; NINDS Parkinson's Disease iPSC Consortium; NINDS Huntington's Disease iPSC Consortium; NINDS ALS iPSC Consortium; Lewis, Patrick A.; Taanman, Jan-Willem; Ryan, Natalie S.; Mahoney, Colin J.; Liang, Yuying; Devine, Michael J.; Sheerin, Una-Marie; Houlden, Henry; Morris, Huw R.; Healy, Daniel; Marti-Masso, Jose-Felix; Preza, Elisavet; Barker, Suzanne; Sutherland, Margret; Corriveau, Roderick A.; D'Andrea, Michael; Schapira, Anthony H V; Uitti, Ryan J.; Slawek, Jaroslaw; Gutmann, Ludwig; Boeve, Bradley F.; Boylan, Kevin; Stoessl, A Jon; Ross, Owne A.; Maragakis, Nicholas J.; Przedborski, Serge E.; Finkbeiner, Steven; Rothstein, Jeffery D.; Wszolek, Zbigniew K.; Rossor, Martin N.; and Hardy, John, "Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research" (2013). Faculty & Staff Scholarship. 2682.
https://researchrepository.wvu.edu/faculty_publications/2682

Source Citation

Wray S, Self M, NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Lewis PA, et al. (2012) Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research. PLoS ONE 7(8): e43099. https://doi.org/10.1371/journal.pone.0043099

Comments

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.