Document Type
Article
Publication Date
2011
College/Unit
Eberly College of Arts and Sciences
Department/Program/Center
Statistics
Abstract
Background
The identification of genes or quantitative trait loci that are expressed in response to different environmental factors such as temperature and light, through functional mapping, critically relies on precise modeling of the covariance structure. Previous work used separable parametric covariance structures, such as a Kronecker product of autoregressive one [AR(1)] matrices, that do not account for interaction effects of different environmental factors.
Results
We implement a more robust nonparametric covariance estimator to model these interactions within the framework of functional mapping of reaction norms to two signals. Our results from Monte Carlo simulations show that this estimator can be useful in modeling interactions that exist between two environmental signals. The interactions are simulated using nonseparable covariance models with spatio-temporal structural forms that mimic interaction effects.
Conclusions
The nonparametric covariance estimator has an advantage over separable parametric covariance estimators in the detection of QTL location, thus extending the breadth of use of functional mapping in practical settings.
Digital Commons Citation
Yap, John S.; Li, Yao; Das, Kiranmoy; Li, Jiahan; and Wu, Rongling, "Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation" (2011). Faculty & Staff Scholarship. 2794.
https://researchrepository.wvu.edu/faculty_publications/2794
Source Citation
Yap, J.S., Li, Y., Das, K. et al. Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation. BMC Plant Biol 11, 23 (2011). https://doi.org/10.1186/1471-2229-11-23
Comments
© 2011 Yap et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.