Document Type
Article
Publication Date
2010
College/Unit
Eberly College of Arts and Sciences
Department/Program/Center
Statistics
Abstract
Despite the fact that genetic imprinting, i.e., differential expression of the same allele due to its different parental origins, plays a pivotal role in controlling complex traits or diseases, the origin, action and transmission mode of imprinted genes have still remained largely unexplored. We present a new strategy for studying these properties of genetic imprinting with a two-stage reciprocal F mating design, initiated with two contrasting inbred lines. This strategy maps quantitative trait loci that are imprinted (i.e., iQTLs) based on their segregation and transmission across different generations. By incorporating the allelic configuration of an iQTL genotype into a mixture model framework, this strategy provides a path to trace the parental origin of alleles from previous generations. The imprinting effects of iQTLs and their interactions with other traditionally defined genetic effects, expressed in different generations, are estimated and tested by implementing the EM algorithm. The strategy was used to map iQTLs responsible for survival time with four reciprocal F populations and test whether and how the detected iQTLs inherit their imprinting effects into the next generation. The new strategy will provide a tool for quantifying the role of imprinting effects in the creation and maintenance of phenotypic diversity and elucidating a comprehensive picture of the genetic architecture of complex traits and diseases.
Digital Commons Citation
Wang, Chenguang; Wang, Zhong; Luo, Jiangtao; Li, Qin; Li, Yao; Ahn, Kwangmi; Prows, Daniel R.; and Wu, Rongling, "A Model for Transgenerational Imprinting Variation in Complex Traits" (2010). Faculty & Staff Scholarship. 2810.
https://researchrepository.wvu.edu/faculty_publications/2810
Source Citation
Wang C, Wang Z, Luo J, Li Q, Li Y, Ahn K, et al. (2010) A Model for Transgenerational Imprinting Variation in Complex Traits. PLoS ONE 5(7): e11396. https://doi.org/10.1371/journal.pone.0011396
Comments
© 2010 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.