Document Type
Article
Publication Date
2009
College/Unit
School of Medicine
Department/Program/Center
Pathology, Anatomy and Laboratory Medicine
Abstract
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from http://www.ncbi.nlm.nih.gov/projects/mapview/.
Digital Commons Citation
Wise, Jasen L.; Crout, Richard J.; McNeil, Daniel W.; Weyant, Robert J.; Marazita, Mary L.; and Wenger, Sharon L., "Human Telomere Length Correlates to the Size of the Associated Chromosome Arm" (2009). Faculty & Staff Scholarship. 2866.
https://researchrepository.wvu.edu/faculty_publications/2866
Source Citation
Wise JL, Crout RJ, McNeil DW, Weyant RJ, Marazita ML, Wenger SL (2009) Human Telomere Length Correlates to the Size of the Associated Chromosome Arm. PLoS ONE 4(6): e6013. https://doi.org/10.1371/journal.pone.0006013
Comments
© 2009 Wise et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.