Date of Graduation
1999
Document Type
Thesis
Degree Type
MS
Committee Chair
Timothy Tracy
Abstract
Embalming fluid, formaldehyde, is commonly used to preserve the body following death. Yet, this practice may confound forensic toxicology studies because of its potential reactivity with drugs. The few studies that have been conducted have focused on the tricyclic antidepressants, nortriptyline and desipramine, demonstrating that these compounds undergo methylation to form amitriptyline and imipramine in the presence of formaldehyde. The present study was designed to investigate several classes of common forensic drugs for their reaction in the presence of formaldehyde. Three concentrations of formaldehyde solutions were used (5, 10, and 20%) at a pH of no adjustment (3-3.5), 7 and 9.5. Analysis of the samples was conducted immediately after introduction to formaldehyde, and at 24 hours, 7 days and 30 days. Results indicate that most compounds appear to undergo a reaction in the presence of formaldehyde, probably forming new chemical entities. Thus, indicating the importance for toxicologists to have a comprehensive understanding of the reactions that occur in embalming fluid and the products formed.
Recommended Citation
James, Devona Gwen, "The degradation of drugs in formaldehyde." (1999). Graduate Theses, Dissertations, and Problem Reports. 10495.
https://researchrepository.wvu.edu/etd/10495