Date of Graduation
2003
Document Type
Thesis
Degree Type
MS
Committee Chair
Hillar Klandorf
Abstract
Study one investigated the ability of uric acid (UA) to scavenge reactive oxygen species (ROS) and the ability of UA to protect against ROS-mediated damage. Hydroxyl and superoxide radical ESR signals were reduced by addition of UA (P< 0.05). UA prevented lipid peroxidation in RAW 264.7 cells exposed to silica (P< 0.015). UA inhibited hydroxyl-mediated damage to λ Hind III DNA. The objective of study two was to determine the effect of changes in plasma UA (PUA) on growth and ascites development in broilers. Chicks were fed a grower diet supplemented with 0.5 moles inosine/kg feed to raise PUA, 15 mg allopurinol/kg body weight/day to lower PUA, or a control diet. Birds were housed in two environmental chambers; one had conditions to promote ascites while the second was held at standard conditions. Although dietary treatment had an effect on PUA, no effect of diet on performance or development of ascites was observed.
Recommended Citation
Stinefelt, Beth M., "Uric acid as an antioxidant and the effect of changes in plasma uric acid concentrations on broiler susceptibility to ascites, and, The effect of diet and strain on growth, feed efficiency, and amino acid retention in hybrid bluegill." (2003). Graduate Theses, Dissertations, and Problem Reports (ETD). 10752.
https://researchrepository.wvu.edu/etd/10752