Date of Graduation
2010
Document Type
Thesis
Degree Type
MS
Committee Chair
George O'Doherty
Abstract
A short asymmetric synthesis of the anti-cancer natural product Rugulactone has been attempted. The synthetic route begins with a mono-Krische allylation of 1,3-propane diol resulting in (S)-hex-5-ene-1,3-diol. Acylation followed by ring closing metathesis (RCM) led to the desired α-pyranone core. Similarly, we focused on the bis-Krische allylation, selective acylation and the RCM sequence towards total synthesis of various αpyranone natural products and their analogues. The progress toward this synthesis is described.
Recommended Citation
Rajaratnam, Melvin, "Applications of Krische allylation towards natural product synthesis." (2010). Graduate Theses, Dissertations, and Problem Reports (ETD). 11127.
https://researchrepository.wvu.edu/etd/11127