Date of Graduation
2001
Document Type
Dissertation
Degree Type
PhD
College
School of Medicine
Department
Not Listed
Committee Chair
Richard D. Dey
Committee Co-Chair
Gregory W. Konat
Committee Member
Mark J. Reasor
Committee Member
Vincent Castranova
Abstract
Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory neuropeptide that inhibits the function of activated macrophages, inhibits the production of proinflammatory cytokines IL-6 and TNF-α and enhances production of the antiinflammatory cytokine IL-10 in lipopolysacharide (LPS)-stimulated peritoneal macrophages. The present study describes the effect of VIP on cell death resulting from LPS exposure on rat alveolar macrophages in vitro. The experiments show that VIP attenuates cell death in LPS-treated alveolar macrophages. The results suggest that the anti-inflammatory action of VIP in LPS-treated lungs may be important in limiting pulmonary inflammatory responses to LPS
Recommended Citation
Poling, William Scott, "Vasoactive intestinal peptide decreases lipopolysaccharide (LPS)-induced cell death in rat alveolar macrophages." (2001). Graduate Theses, Dissertations, and Problem Reports. 12918.
https://researchrepository.wvu.edu/etd/12918