Semester
Fall
Date of Graduation
2004
Document Type
Thesis
Degree Type
MS
College
Statler College of Engineering and Mineral Resources
Department
Mechanical and Aerospace Engineering
Committee Chair
Nilay Mukherjee.
Abstract
Prechondrocytes exhibit a change in their actin cytoskeletal arrangement when subjected to loading. This study looks at the implications of the altered solid-fluid interactions due to this change. A 2-D Finite element model of a cell was developed. A solid-fluid interaction solution procedure was validated and used to determine fluid flow/pressure in a cell when subject to deformation. These values were then used to calculate fluid flow induced stresses on individual actin fibers. The results suggest that prechondrocytes alter their cytoskeletal structure to reduce stresses as a result of fluid flow due to deformation of the cell.
Recommended Citation
Viswanathan, Sundar, "Finite element analysis of interaction between actin cytoskeleton and intracellular fluid in prechondrocytes and chondrocytes subjected to compressive loading" (2004). Graduate Theses, Dissertations, and Problem Reports. 1757.
https://researchrepository.wvu.edu/etd/1757