Semester
Fall
Date of Graduation
2003
Document Type
Thesis
Degree Type
MS
College
School of Pharmacy
Department
Pharmaceutical Sciences
Committee Chair
Paula Jo Stout.
Abstract
The vitamin folic acid has received considerable attention in the 1990s because of its preventative role against diseases such as neural tube defects, cardiovascular diseases, and psychiatric illness.;A primary concern is the pharmaceutical quality, potency, and efficacy of commercially available folic acid products and label claims. The results showed that there has been significant progress since the 1990's in the improved quality of commercially available folic acid products in meeting USP standards.;Products were also tested in physiologically relevant solutions. Most notably, all the tested products failed to release more than 75% of the active ingredient in 60 minutes in simulated gastric fluid. While some excipient-related factors were preliminarily considered, it was ultimately hypothesized that the failure may be related to the folic acid pH-solubility profile, confirmed by the increased release rate of folic acid from buffered tablets compared with non-buffered tablets, when constant surface area dissolution was maintained.
Recommended Citation
Younis, Islam Rasem, "Pharmaceutical quality performance of folic acid supplements" (2003). Graduate Theses, Dissertations, and Problem Reports. 1812.
https://researchrepository.wvu.edu/etd/1812