Semester
Spring
Date of Graduation
2005
Document Type
Thesis
Degree Type
MS
College
School of Medicine
Department
Microbiology, Immunology, and Cell Biology
Committee Chair
Susan Lemieux
Committee Co-Chair
L. A. Hornak
Abstract
Noninvasive functional magnetic resonance imaging (fMRI) methods may provide new ways to detect and track renal hemodynamic changes in-vivo. In this thesis, two fMRI methods were correlated with simultaneous invasive hemodynamic measurements. A particular goal of this thesis was to measure the relative contributions of oxygenation and perfusion changes to changes in the relaxation rate, T2*. Also, an MRI compatible motion detector was built and along with the invasive probes was interfaced to a data acquisition system for use during scanning. Drug-induced changes in renal oxygenation and blood flow were measured by BOLD- & ASL-MRI noninvasively, while a dual oxygenation/perfusion optical-probe was used for the invasive measurements. Six sets of results were obtained. Values of T2*, LDF and pO2 correlated in four of the data sets while the other two were discrepant. BOLD images were of high quality while ASL perfusion maps were of inadequate spatial resolution and poor quality.
Recommended Citation
Garugu, Rajesh K., "Functional MRI of rat kidney using BOLD & ASL techniques" (2005). Graduate Theses, Dissertations, and Problem Reports. 2233.
https://researchrepository.wvu.edu/etd/2233