Semester
Fall
Date of Graduation
2008
Document Type
Thesis
Degree Type
MS
College
Eberly College of Arts and Sciences
Department
Chemistry
Committee Chair
George O'Doherty.
Abstract
A short asymmetric synthesis of (R)-(+)-Goniothalamin oxide was developed and synthesized using a Leighton asymmetric allylation reaction and Grubbs ring-closing metathesis. (R)-(+)-Goniothalamin oxide is a styryl lactone that exhibits anti-cancer activity against a variety of cancer cell lines including MCF-7, T47D, and MDA-MB-231. The methododology of asymmetric allylation is also demonstrated on intermediates of RK-397, which is a 32-membered oxopolyene macrolide with anti-cancer activity.
Recommended Citation
Harsh, Philip R., "Applications of asymmetric allylation reactions towards natural product synthesis" (2008). Graduate Theses, Dissertations, and Problem Reports. 2671.
https://researchrepository.wvu.edu/etd/2671
