Semester
Fall
Date of Graduation
2007
Document Type
Thesis
Degree Type
MS
College
Eberly College of Arts and Sciences
Department
Chemistry
Committee Chair
George A O'Doherty
Abstract
The enantioselective syntheses of digitoxigen 2,6-dideoxy-beta-L-ribo-hexopyranoside, its analogues and digitoxin monosaccharide analogues have been achieved. Key to this approach is the iterative application of the palladium-catalyzed glycosylation reaction, reductive 1,3-transposition and diastereoselective dihydroxylation. Anticancer tests showed that these analogues have even better anticancer activities.
Recommended Citation
Xin, Wenjun, "De novo asymmetric synthesis of digitoxin based carbohydrate libraries" (2007). Graduate Theses, Dissertations, and Problem Reports. 4351.
https://researchrepository.wvu.edu/etd/4351
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