Date of Graduation
Eberly College of Arts and Sciences
George A O'Doherty
The enantioselective syntheses of digitoxigen 2,6-dideoxy-beta-L-ribo-hexopyranoside, its analogues and digitoxin monosaccharide analogues have been achieved. Key to this approach is the iterative application of the palladium-catalyzed glycosylation reaction, reductive 1,3-transposition and diastereoselective dihydroxylation. Anticancer tests showed that these analogues have even better anticancer activities.
Xin, Wenjun, "De novo asymmetric synthesis of digitoxin based carbohydrate libraries" (2007). Graduate Theses, Dissertations, and Problem Reports. 4351.