Semester
Fall
Date of Graduation
2011
Document Type
Thesis
Degree Type
MS
College
Statler College of Engineering and Mineral Resources
Department
Industrial and Managements Systems Engineering
Committee Chair
Feng Yang
Committee Co-Chair
Robert Creese
Committee Member
Majid Jaridi
Abstract
This thesis is concerned with developing two-stage Bayesian optimum design procedure in nanotoxicology with simulation experiments. The proposed design method adopts suitable nonlinear dose response curve and non-constant variance model in experimental modeling, which more adequately represents the desirable properties of bioassay-experiment. A multiple objective genetic algorithm were used to select best set of non-dominated experiments on Pareto front. The proposed approach has been shown to provide better design than traditional experiment method in terms of D-optimum design and A-optimum design.
Recommended Citation
Wang, Kai, "Efficient Design Of Biological Experiments For Dose-Response Modeling In Nanomaterial Toxicology Studies" (2011). Graduate Theses, Dissertations, and Problem Reports. 483.
https://researchrepository.wvu.edu/etd/483