Semester
Spring
Date of Graduation
2013
Document Type
Thesis
Degree Type
MS
College
College of Physical Activity and Sport Sciences
Department
Exercise Physiology
Committee Chair
I Mark Olfert
Committee Co-Chair
Stephen Alway
Committee Member
Emidio Pistilli
Abstract
Angiogenesis is an important adaptation to exercise, occurring in response to a multitude of different stimuli including: shear stress, mechanical stretch, ischemia, electrical stimulation, and exercise. Current thinking suggests skeletal muscle angiogenesis is a temporal process controlled by a balance between positive and negative angiogenic proteins. But there is limited information on what molecular mediators control skeletal muscle angiogenesis in this time line, creating a critical need to clarify how individual protein responses regulate physiologic skeletal muscle angiogenesis in response to exercise training and/or physical deconditioning. Our objective is to characterize the temporal expression of several key positive (VEGF, MMP-2, MMP-9, nucleolin) and negative (TSP-1, endostatin) angiogenic factors under basal conditions, after acute exercise, in response to training, and after detraining. The central hypothesis is that training and deconditioning will cause temporally coordinated changes in positive and negative angiogenic regulators in response to exercise training, which will be reversed during detraining.
Recommended Citation
Olenich, Sara A., "Temporal Expression of Key Angioregulatory Proteins in Response to Exercise and Detraining" (2013). Graduate Theses, Dissertations, and Problem Reports. 4986.
https://researchrepository.wvu.edu/etd/4986