Semester
Summer
Date of Graduation
2021
Document Type
Dissertation
Degree Type
PhD
College
School of Pharmacy
Department
Pharmaceutical Sciences
Committee Chair
Paul R. Lockman
Committee Member
R. Alfredo C. Siochi
Committee Member
Werner Geldenhuys
Committee Member
Lori A. Hazlehurst
Committee Member
Marina Galvez
Abstract
This dissertation (a) provided an in depth literature review of methods to disrupt the BBB/BTB and improve therapeutic distribution to brain tumors, (b) evaluated the use of azacitidine as a single agent therapy for the treatment of brain metastasis of breast cancer and a potential molecular mechanism by which brain tropic cells are sensitized to hypomethylating agents, (c) determined the impact cannabidiol has on P-glycoprotein mediated efflux at the blood-brain barrier and its potential for use as a single agent treatment for metastatic brain tumors, (d) developed a preclinical radiation therapy protocol for use in small animals and in vitro systems, (e) evaluated the impact radiation therapy has on blood-brain barrier integrity in normal and pathological brain, and (f) provided a discussion on the mathematical models used to evaluate blood-brain barrier pharmacokinetics in both normal and pathophysiological conditions.
Recommended Citation
Sprowls, Samuel A., "Bypassing the Blood-Brain Barrier: A Physical and Pharmacological Approach for the Treatment of Metastatic Brain Tumors" (2021). Graduate Theses, Dissertations, and Problem Reports. 8261.
https://researchrepository.wvu.edu/etd/8261
Included in
Animal Experimentation and Research Commons, Cancer Biology Commons, Medicinal Chemistry and Pharmaceutics Commons, Neoplasms Commons, Neurosciences Commons, Oncology Commons, Other Neuroscience and Neurobiology Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Other Physical Sciences and Mathematics Commons