Date of Graduation
1972
Document Type
Dissertation
Committee Member
R.E. McCafferty
Committee Member
D.P. Westfall
Committee Member
J.J. McPhillips
Committee Member
W.W. Fleming
Committee Member
C.J. Malanga
Abstract
This study was undertaken to further define the characteristics of subsensitivity produced by chronic administration of cholinesterase inhibitors and to attempt to elucidate a possible mechanism by which it occurs. Administration of disulfoton, echothiophate , parathion and OMPA to rats for eight days resulted in a decreased sensitivity of segments of ileum to carbachol and a marked inhibition of both true and total cholinesterase. The results indicate that a relationship between the degree of subsensitivity and the extent of cholinesterase inhibition may exist.
Recommended Citation
Foley, Dennis Joseph, "A Comparison Of The Effects Of Acute And Subacute Inhibition Of Cholinesterase On The Sensitivity Of Rat Tissues To Drugs" (1972). Graduate Theses, Dissertations, and Problem Reports. 8859.
https://researchrepository.wvu.edu/etd/8859