Document Type
Article
Publication Date
3-14-2022
College/Unit
Davis College of Agriculture, Natural Resources and Design
Department/Program/Center
Division of Plant and Soil Sciences
Abstract
The shikimate pathway, the seven enzymatic steps that synthesize chorismate from phosphoenolpyruvate and erythrose 4-phosphate, produces the last common precursor of the three aromatic amino acids. It is firmly established that all seven enzymes are present in plastids, and it is generally accepted that this organelle is likely the sole location for production of chorismate in plants. However, recently a growing body of evidence has provided support for a previous proposal that at least portions of the pathway are duplicated in the cytosol, referred to as the Dual Pathway Hypothesis. Here I revisit this obscure hypothesis by reviewing the findings that provided the original basis for its formulation as well as more recent results that provide fresh support for a possible extra-plastidial shikimate pathway duplication. Similarities between this possible intercompartmental metabolic redundancy and that of terpenoid metabolism are used to discuss potential advantages of pathway duplication, and the translational implications of the Dual Pathway Hypothesis for metabolic engineering are noted.
Digital Commons Citation
Lynch, Joseph H., "Revisiting the dual pathway hypothesis of Chorismate production in plants" (2022). Faculty & Staff Scholarship. 3101.
https://researchrepository.wvu.edu/faculty_publications/3101
Source Citation
Joseph H Lynch, Revisiting the dual pathway hypothesis of Chorismate production in plants, Horticulture Research, Volume 9, 2022, uhac052, https://doi.org/10.1093/hr/uhac052
Comments
© The Author(s) 2022.Published by Oxford University Press on behalf of Nanjing Agricultural University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
This article received support from the WVU Libraries' Open Access Author Fund.