Document Type

Article

Publication Date

Summer 7-1-2024

College/Unit

School of Medicine

Department/Program/Center

Cardiovascular and Thoracic Surgery

Abstract

Atrial fibrillation (Afib) is a prevalent arrhythmia, significantly impacting patient health and healthcare systems. This study addresses the increasing Afib burden by comparing the outcomes of transcatheter and surgical interventions, specifically targeting patients aged 50-75 years with symptomatic non-valvular Afib. The study hypothesizes that while catheter-based interventions might lead to fewer immediate adverse events, they could result in higher Afib recurrence rates compared to surgical methods.

This prospective, single-center, randomized controlled trial will evaluate the safety and efficacy of two primary strategies: catheter ablation combined with percutaneous left atrial appendage occlusion (P-LAAO) and surgical ablation combined with surgical left atrial appendage occlusion (S-LAAO). A total of 100 patients will be enrolled and followed for one year post-intervention, focusing on both clinical outcomes and quality of life measures.

The study aims to fill a significant gap in current research by providing robust comparative data on these interventions, potentially informing future clinical guidelines and treatment protocols for Afib management.

Available for download on Friday, June 11, 2027

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