Semester
Spring
Date of Graduation
2006
Document Type
Thesis
Degree Type
MS
College
School of Pharmacy
Department
Pharmaceutical Systems and Policy
Committee Chair
Lesley-Ann Miller.
Abstract
This study is an economic evaluation of currently recommended colorectal cancer (CRC) screening procedures, and strategies that incorporate chemopreventive options such as aspirin or a cycooxygenase-2 inhibitor. A decision analysis model was constructed to compare alternative CRC screening strategies. A Markov model was employed to simulate the natural history of CRC. Quality adjusted life years were used as the primary outcome measure. The base case analysis represents the overall cost and effectiveness associated with each screening strategy. Incremental cost-effectiveness ratios (ICERs) were calculated for each screening strategy. One-way sensitivity analyses were performed to assess the factors that have the greatest effect on the cost-effectiveness of screening. The most cost-effective screening strategy was Fecal Occult Blood Test (FOBT); followed by FOBT plus aspirin, colonoscopy, and colonoscopy plus aspirin. The ICER of FOBT was {dollar}13,014.85 compared to Natural History. The model was sensitive to the costs of FOBT, colonoscopy, and aspirin.
Recommended Citation
Coffindaffer, Jarrett W., "Colorectal cancer: Cost-effectiveness of screening and chemoprevention in average risk males" (2006). Graduate Theses, Dissertations, and Problem Reports. 2449.
https://researchrepository.wvu.edu/etd/2449